Solutions

Our platform continuously integrates dozens of external databases of information about drugs, genetic mutations, mutation frequencies in sub-populations, and clinical outcomes. This information is aggregated and converted to the Semantic Web technology used by our Knowledge Base.

PanGenX geneticists select the highest quality peer-reviewed clinical studies about drug-gene interactions and represent their findings in our knowledge base. To ensure the highest quality standards, the work of our geneticists is reviewed and monitored by members of our distinguished Clinical Review Board.

The illustration on the right shows how the PanGenX knowledge base is organized.

The heart of this database is comprised of nodes representing specific drug-gene interactions, such as the one shown in the center above. This central node’s links tie back to the original published article (at the top), to the drug under investigation (middle-right), to a specific genetic mutation (middle-left), to the population of the study (lower-left) and to the observed and measured outcomes (lower-right).

Our interactive, browser-based Knowledge Viewer application provides a graphical interface to our knowledge base. In seconds the user has access to the findings of hundreds of the highest quality scientific papers that can be viewed, explored, navigated and compared in a normalized, consistent manner. The results are shown in tables, charts and network graphs.

Beyond visualization the platform includes a modeling capability that provides probably the most valuable insight of all: the ability to predict outcomes of drugs based on patient populations and ethnicities.